Speakers

Biography

Junying Zhang is a chief laboratory technician and a practicing physician devoted to researching salmonella and human papillomavirus in medical microbiology. Related research has been published in Chinese science and technology core journals, 12 papers, 3SCI articles, and a medical book. Currently, Junying Zhang is engaged in Clinical Laboratory work and related research in the Clinical Laboratory Department at Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Abstract

Background: Human papillomavirus (HPV) infection among females is the cause of cervical cancer and genital warts. In China, the HPV vaccination rate and the target population screening rate among females are low, and the aims of this study on the genotype distribution and prevalence of HPV infection were to provide more targeted strategies for the prevention and treatment of cervical cancer and HPV-related diseases.

Methods: Polymerase chain reaction-reverse dot blot (PCR-RDB) was adopted for the HPV genotyping test, and the prevalence and 23 genotypes distribution of HPV infections among 181,705 women in Chengdu from 2013 to 2020 were analyzed.

Results: The overall prevalence rate of HPV infection among 181,705 cases was 23.28%; HR-HPV prevalence in the age group<20 years, 60–69 years, and ≥70 years were higher than the overall prevalence. The prevalence of HPV showed a bimodal U-shaped curve with age; the first and second peaks commonly occurred among females<20 years old (42.97%) and 60–69 years old (37.56%), respectively. The top five genotypes of HPV infection among females in Chengdu were HPV52/16/58/81/53. Single infection (73.26%) was the main HPV infection pattern, followed by double infection (19.17%) and multiple infection (7.57%). The infection rate of HPV showed a gradual decline as the patterns of HPV coinfections increased. Low-risk and high-risk coinfection was higher in low-risk HPV infection (43.68%) and lower in high-risk HPV infection (13.59%). The prevalence of genotypes −6 and −81 infection was the second highest at the age group of 20 and 40–59, respectively, while the prevalence of HPV16 was the highest at≥70 among 23 genotypes among the 181,705 women.

Conclusions: The prevalence of HPV infections among women in Chengdu is higher than in certain developed cities; among the five vaccines available, the nonavalent vaccine is more suitable for Chengdu females. For young females, prioritizing vaccination is essential. Double screening for HPV DNA is important in middle-aged women (30–49 years), and screening should not be lacking in older women (>65 years). Additionally, for patients with genital warts, it is necessary to screen for high-risk HPV infection and provide appropriate management and treatment.