Dengue is a viral fever in humans caused by 4 serotypes of flavivirus. It is spread by the bite of infected Aedes mosquitoes. It is associated with multisystem involvement. The case series presented here depicts unusual manifestations of dengue infection with hypoplastic anaemia, hepatitis, pancreatitis, and encephalopathy. The cases were diagnosed based on a history of dengue with subsequent persistence of pancytopenia, presence of hepatitis, pancreatitis, and encephalopathy with serological evidence of dengue, after ruling out other aetiologies and based on laboratory investigations.
Bone marrow revealed pancytopenia with hypocellular marrow diagnosing hypoplastic anemia, transaminitis, and rise of lipase and amylase enzymes with symptoms diagnosed hepatitis, pancreatitis, and finally impairment of consciousness with electroencephalogram-diagnosed encephalopathy.
The importance of the case series lies in the fact that atypical manifestations may occur in dengue patients, causing diagnostic and treatment dilemmas.
Keywords: dengue, hypoplastic anemia, hepatitis, pancreatitis, encephalopathy