Miami, FL, USA
3rd Edition of Infectious Diseases World Conference 2026
Speakers - 2025
Francis J Castellino
- Designation: University of Notre Dame
- Country: USA
- Title: Host Pathogen Interactions Govern Streptococcal Virulence
Abstract
The innate immune system plays a critical role in the pathogenicity of Streptococcal pyogenes (GAS) infections. The hemostasis, fibrinolytic, and inflammatory systems play pivotal roles in this regard. This cascade begins with the initiation of the blood coagulation system via the intrinsic (contact) pathway, which has a strong interdependence with inflammation via bradykinin release. The fibrinolytic system also plays an important role in the virulence of many GAS strains due to plasminogen binding to GAS receptors and its activation to the strong protease, plasmin, on the cell surface. This process leads to a proteolytic bacterial surface, which can assist its dissemination into deep tissue sites with concomitant development of maladies such as sepsis and necrotic fasciitis. Thus, the ability of GAS to result in more than self-limiting infections greatly depends on its conscription of host systems.
3rd Edition of the Infectious Diseases World Conference (IDWC 2026) The 3rd Edition of the Infectious Diseases World Conference (IDWC 2026) ...
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